Ways to Use Vinegar and Baking Soda to Clean Every Room in Your Home Recipes and step-by-step instructions. If you want to cut down on the number of chemical-filled cleaners in your house but you still want to keep everything clean, the combination of vinegar and baking soda is a great eco-friendly alternative for removing stains and smells. The chemical reaction between alkaline baking soda (sodium bicarbonate) and acidic vinegar creates carbon dioxide bubbles that help lift away stubborn dirt. Explore Easy recipes using vinegar and baking soda to clean all sorts of messes around your house. Tips for Using Vinegar and Baking Soda to Clean Mix a fresh batch each time you need it and use it right away. The best type of vinegar to use is distilled white vinegar. There are no dangerous fumes released from mixing baking soda and vinegar, but you may want to stand back as the reaction does release carbon dioxide. Drain Cleaner This mixture can be used to refresh a stinky drain and clear m